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Hypnotics and Sedatives

For hypnotics: Nitrazepam is a drug of choice over barbiturates. For sedatives and tranquilisers: Diazepam is a benzodiazepine tranquiliser with sedative, muscle relaxant, amnesic properties. It is used to treat anxiety and tension states.

Barbiturates
Barbiturates cross the placenta and appear in the fetus. After prolonged continuous usage during a large part of pregnancy, they can give rise to hypotension, reduced respiratory function and hypothermia in the newborn child. Continuous treatment during pregnancy and administration during labour should therefore be avoided.

Benzodiazepins
Benzodiazepins cross the placenta and appear in the fetus and may, after continuous administration during a large part of pregnancy, give rise to hypotension, reduced respiratory function and hypothermia in the newborn child. Continuous treatment during pregnancy and administration of high doses during labour should therefore be avoided. Withdrawal symptoms in newborn infants have occasionally been reported with this class of drugs.

Other hypnotics and sedatives
Other hypnotics and sedatives like chloral hydrate, chlormethiazole, hydroxyzine and valerian are considered safe during pregnancy.

Products:	Diazepam
For Children:	Safe
For Pregnant Women:	Contra-indicated
For Breastfeeding Mothers:	Safety not established
*Contra-indications:**	Respiratory depression
Caution:	Can cause psychological/physical dependence

*Not to be used in the conditions stated, because it could cause complications.

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