Malaria
drugs (Antimalarials)
Pyrimethamine
Pyrimethamine may interfere with
folic acid metabolism. Animal experiments have shown that administration
of very high doses during the baby's organ development may give rise to
birth defects typical of folic acid antagonism. If pyrimethamine
is given during pregnancy, folic acid supplementation may be required.
Chloroquine
Chloroquine is useful in the suppression
and treatment of malaria. It has a rapid schizonticidal effect. Chloroquine
and related substances may cause neurological disturbances in the fetus
and interference with hearing, balance and vision. The use of these
drugs in the prophylaxis of malaria is accepted because the small risk
to the fetus with the low doses used is outweighed by the benefits to the
mother and fetus. The use of higher doses in the treatment of malaria
and in the second line treatment of liver amoebiasis is accepted because
the lifesaving benefits of the treatment to the mother and the fetus outweigh
the risk.
Quinine
Quinine, a highly active blood schizonticide
also suppresses the asexual cycle of development of malarial parasites
in the erythrocytes (red blood cells). Quinine (and quinidine) in high
doses causes fetal injuries in the form of deafness, developmental disturbances
and malformations of the extremities and cranium. Its ability to
induce uterine contractions also causes a risk of abortion.
Pyrimethamine with Sulfadoxine
Pyrimethamine may interfere with
folic acid metabolism. Sulfadoxine may cause jaundice in babies during
the first month of life by displacing bilirubin from plasma albumin.
Sulfadoxine should therefore be avoided as far as possible during the last
month of pregnancy.
Products: |
Chloroquine, Quinine |
For Children: |
Reduced dose necessary |
For Pregnant Women: |
High doses may affect the baby |
For Breastfeeding Mothers: |
Caution |
Contra-indications*: |
Renal and liver impairment, epilepsy |
Caution: |
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